New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

In Vanuatu, small-scale farmers’ subsistence still largely relies on the sustainable use and maintenance of a wide-ranging biodiversity out of which root and tuber crops provide the bulk of daily subsistence. In neighboring countries, foreign influence since the first European contacts, further associated changes and the introduction of new crop species have induced a loss of cultivated diversity. This paper presents a baseline study of the diversity of root and tuber crops in ten communities throughout Vanuatu. In a context where (...) the smallholders’ agrosystems are increasingly considered as key components for the global conservation of crop genetic resources, this study provides clues to better understand the effective roles of biodiversity in traditional agrosystems. It also provides insights on the rationale behind the constitution of agricultural portfolios and discusses how the cultivated diversity allows communities to cope with changes and pressures. The paper also shows that recently introduced crops neither seem to have compromised agricultural diversity nor drastically changed the agrosystems in Vanuatu. On the contrary, such crops are used by farmers to strengthen the resilience of their agrosystems. A discussion then presents the idea of continuity through change and novelty as a critical factor for resilience. The paper concludes by discussing the role of indigenous agriculture and culture in ensuring food security and in development strategies in a larger context. (shrink)

This article, corresponding to a part of the restitution of a financed international research project between France, Brazil, Canada, Italy and Belgium, aims to offer a modelisation and qualitative evaluation of mediation care settings based on an original methodological tool that involves identifying the typical games at the foundations of creativity, following a multidisciplinary perspective. Therapeutic mediations are settings or devices organised around a “pliable medium”, often artistic, like painting, modeling, writing, ​and theatre, which are very widespread in institutional practices, (...) both in France and abroad. The scientific objectives of this research consist in a multi-disciplinary exploration (anthropology, criminology, neuroscience, clinical psychology) of the process of creative symbolisation understood as a process of transformation involving play. According to this orientation, play can be defined as a psychic process whereby a subjective experience can be explored with pleasure, and consequently symbolised and appropriated. Our fundamental and original hypothesis is that play is at the source of the creative process, conceived as a work of metabolisation by the psyche of playful experiences during the different stages of life. The review of the understanding of play in psychoanalysis, anthropology, criminology and neuroscience emphasises the richness of this model and the importance of reflecting on the typical games in the field of psychic care. A clinical example of treatment in a pictorial therapeutic mediation setting of a child with psychotic disorders makes it possible to identify a number of typical games as well as the modalities of interpretation of the therapists through play. These multidisciplinary studies lead to the presentation of a general table of typical games, and these first results highlight the richness of identifying typical games in clinical settings. Ultimately, the multidisciplinary approach shows the interest of the model of play in the evaluation of therapeutic mediation settings, with a convergence of the different disciplines emphasising the pertinence of this model. The scientific impact of this research overlaps with its societal impact, through the development of innovative tools for evaluating therapeutic mediations, in order to take account of the evolution of the different forms of social expression of psychic suffering. (shrink)

This paper shows that Aristotle's De Interpretatione does not separate syntax from semantics. Linguistic sentences are not syntactic entities, and non-linguistic meanings are not semantic propositions expressed by linguistic sentences. In fact, Aristotle resorts to a mental conception of meaning, distinguishing linguistic meanings in a given language from non-linguistic mental contents in relation to actual things: while the former are not the same for all, the latter are shared by everyone. Aristotle is not a modern logician, like Boole, Frege, or (...) Russell, in so far as a mental conception of meaning does not reveal an abstract semantics for a syntactic language. (shrink)

Aristotle’s Prior Analytics identifies deductions simpliciter with inferential necessity, so that a deduced conclusion is necessarily inferred from some premises. Modern logical reconstructions claim that inferential necessity in Aristotle corresponds to logical validity. However, this logical reconstruction fails on two accounts. First, logical validity does not highlight Aristotle’s distinction between inferential necessity and predicative necessity, meaning that the inferential necessity of a deduction is not of the same kind as the predicative necessity of a non‑deductive argument. Second, logical validity does (...) not explain the relevance of Aristotle’s distinction between complete and incomplete deductions. Logicians speak of complete deduction by adding the term “obvious” or “transparent” to logical validity, and then criticize Aristotle’s view for being unclear. However, Aristotle’s position is not confronted with this difficulty. There is nothing to add to inferential necessity, which already means complete deducibility, as opposed to incomplete deducibility, deemed to be potentially complete. Accordingly, the Prior Analytics reduces the incomplete deductions to the complete deductions in order to prove the potential, inferential necessity of the incomplete deductions. Logical validity would have been faithful to Aristotle’s text, if it had been possible to coin a notion of potential validity, distinct from both validity and invalidity. (shrink)

Contrairement à une idée reçue, les religions fabriquent de nombreuses différences : c’est une façon de donner sens au monde. La difficulté vient de ce qu’elles ne coïncident pas avec les différenciations et les séparations modernes. Du coup, les différences religieuses du passé peuvent s’effacer, mais aussi s’exacerber dans des formes identitaires. Mais elles peuvent aussi rappeler à la modernité que le franchissement de certaines limites en certains domaines l’expose au risque de « déraillements » .Contrary to a received idea, (...) religions create a great many differences in their attempts to give meaning to the world. The difficulty arises from the fact that these differences do not coincide with the differentiations and separations of modern times. As a result, the religious differences of the past can fade away, but they can also become exacerbated through forms of identity-building. Nevertheless, they can also be a reminder to modern times that crossing over certain boundaries in certain areas can create risks of “derailment”. (shrink)

When it was first published in French in 1980, The Ordinary Man of Cinema signaled a shift from the French film criticism of the 1960s to a new breed of film philosophy that disregarded the semiotics and post-structuralism of the preceding decades. Schefer describes the schizophrenic subjectivity the cinema offers us: the film as a work projected without memory, viewed by (and thereby lived by) a subject scarred and shaped by memory. The Ordinary Man of Cinema delineates the phenomenology of (...) movie-going and the fleeting, impalpable zone in which an individuals personal memory confronts the cinemas ideological images to create a new way of thinking. It is also a book replete with mummies and vampires, tyrants and prostitutes, murderers and freaksfigures that are fundamental to Schefers conception of the cinema, because the worlds that cinema traverses (our worlds, interior and exterior) are worlds of pain, unconscious desire, decay, repressed violence, and the endless mystery of the body. Fear and pleasure breed monsters, and such are what Schefers emblematic "ordinary man" seeks and encounters when engaging in the disordering of the ordinary that the movie theater offers him. Among other things, Schefer considers "The Gods" in 31 brief essays on film stills and "The Criminal Life" with reflections on spectatorship and autobiography. While Schefers book has long been standard reading in French film scholarship, until now it has been something of a missing link to the field (and more broadly, French theory) in English. It is one of the building blocks of more widely known and read translations of Gilles Deleuze (who cited this book as an influence on his own cinema books) and Jacques Rancière. (shrink)

Véronique Adam : Les neurosciences ne s’intéressent que depuis très récemment à l’olfaction. Pourriez‑vous expliquer pourquoi ce sens est devenu un objet d’étude plus prégnant? Jean-Louis Millot : En fait, l’olfaction demeure encore peu étudiée comparée à d’autres modalités sensorielles. De manière générale, les neurosciences cognitives actuelles, comme d’autres investigations scientifiques chez l’homme par le passé, se focalisent davantage sur les compétences cognitives complexes, telles qu...

, which uses the intuitionistic propositional calculus, with the only connective →. It is very important, because the well known Curry-Howard correspondence between proofs and programs was originally discovered with it, and because it enjoys the normalization property: every typed term is strongly normalizable. It was extended to second order intuitionistic logic, in 1970, by J.-Y. Girard [4], under the name of system F, still with the normalization property.More recently, in 1990, the Curry-Howard correspondence was extended to classical logic, following (...) Felleisen and Griffin [6] who discovered that the law of Peirce corresponds to control instructions in functional programming languages. It is interesting to notice that, as early as 1972, Clint and Hoare [1] had made an analogous remark for the law of excluded middle and controlled jump instructions in imperative languages.There are now many type systems which are based on classical logic; among the best known are the system LC of J.-Y. Girard [5] and the λμ-calculus of M. Parigot [11]. We shall use below a system closely related to the latter, called the λ c -calculus [8, 9]. Both systems use classical second order logic and have the normalization property.In the sequel, we shall extend the λ c -calculus to the Zermelo-Frænkel set theory. The main problem is due to the axiom of extensionality. To overcome this difficulty, we first give the axioms of ZF in a suitable (equivalent) form, which we call ZF ɛ. (shrink)

Au sein de la science politique les approches sociologiques sont les plus réceptives à la psychologie sociale entendue comme cognition sociale. L'étude du politique a longtemps privilégié des objets institutionnels et l'influence des concepts de la psychologie sociale y est ancienne . Aujourd'hui de nouvelles questions de société et formes de mobilisation, comme l'intégration des minorités ou les rapports de genre, apparaissent. L'analyse des institutions et des objets classiques est renouvelée. Les problématiques font une grande place à la dynamique des (...) représentations, aux modes de raisonnement et d'inférences, aux formes de connaissance, à l'utilisation de l'information par les acteurs. Ainsi la science politique utilise de plus en plus les concepts et méthodes des approches cognitives.Within the field of political science, sociological approaches are more and more akin to social psychology understood as social cognition. The study of politics has long been focused on institutional subjects and influenced by concepts derived from social psychology . Today, new questions about society and new forms of mobilization such as the integration of minorities or gender relationships are emerging. As a result, a renewed analysis of institutions and traditional objects is required. Current problems are more and more centred on the dynamics of representations, on ways of reasoning, on forms of knowledge and on the use of information. Political science is increasingly using the concepts and methods of cognitive approaches. (shrink)

We describe here a simple method in order to obtain programs from proofs in second-order classical logic. Then we extend to classical logic the results about storage operators proved by Krivine for intuitionistic logic. This work generalizes previous results of Parigot.

Inλ-calculus, the strategy of leftmost reduction (“call-by-name”) is known to have good mathematical properties; in particular, it always terminates when applied to a normalizable term. On the other hand, with this strategy, the argument of a function is re-evaluated at each time it is used.To avoid this drawback, we define the notion of “storage operator”, for each data type. IfT is a storage operator for integers, for example, let us replace the evaluation, by leftmost reduction, ofϕτ (whereτ is an integer, (...) andϕ anyλ-term) by the evaluation oftτϕ. Then, this computation is the same as the following: first computeτ up to some reduced formτ 0, and then applyϕ toτ 0. So, we have simulated “call-by-value” evaluation within the strategy of leftmost reduction.The main theorem of the paper (Corollary of Theorem 4.1) shows that, in a second orderλ-calculus, using Gödel's translation of classical intuitionistic logic, we can find a very simple type (or specification) for storage operators. Thus, it gives a way to get such operators, which is to prove this type in second order intuitionistic predicate calculus. (shrink)

Christianism often mentions perfumes. Its liturgy based on Scripture uses incense and balm. A reading from the Bible and the lives of saints reveals many extraordinary perfumes (“odours of sanctity”). The Virgin Mary holds extreme importance among saints and it is quite common to see her spreading miraculous fragrances. These are subtle, discrete but pleasant signals from Heaven. They are sent to everyone in order to convert non‑believers or turn back believers to the faith in God. The divine origin of (...) perfumes is tied up with the memories and hopes from Paradise. It marks bodies escaping from death and entering into eternal life. (shrink)

Philosophical hermeneutics developed by the German philosopher Hans-Georg Gadamer and founded on interpretation as explicit form of comprehension generated a debate on contemporary hermeneutics about texts written at different periods of time from those in which they must then be applied. This debate is necessarily very instructive for the jurist when he interprets texts and creates positive law to produce a determined effect on recipients. Comprehension as participation in truth involves questioning and an interpretation devoid of prejudices. Illustration of hermeneutics (...) in law demonstrates that interpretation related to comprehension is strictly bound to the question of application bearing in mind that application does not only consist in concretizing comprehension, it constitutes his nucleus. It follows that hermeneutics oscillates between a theoretical and practical meaning. Regarding the concept of a presumption it is perceived as an instrumental necessity and a necessary corollary of interpretation in that it anticipates on the meaning found on the possibility. It is specified in a context of legal hermeneutics that it is necessary to distinguish the interpretation of the observer from the one of the player such the judge put in the performative position. (shrink)

Le débat entre E. Peterson et C. Schmitt des années 1930 sur le théologico-politique a laissé une question irrésolue qui resurgit dans les sociétés pluralistes postmodernes. La nouvelle théologie politique du théologien de Münster J.B. Metz la réactive en proposant au fil de son oeuvre une éthique politique comme éthique du changement social. En sous-estimant le caractère polémique du politique et la fragilité des sujets dont l’identité est devenue précaire, Metz parvient sûrement à une théologie critique mais demeure incertain sur (...) le versant de l’invention politique proprement dite de la société. L’opposition de J. Milbank à cette théologie politique ne dirime pas la question et demeure dans un geste uniquement critique en proposant une contre-éthique, une contre-ontologie, un contre-royaume par la mise en oeuvre de pratiques narratives, rituelles et sociales. Un débat entre la théologie de J.B. Metz et la pensée communautariste de S. Hauerwas pourrait peut-être affronter la question de l’avènement des sujets capables d’invention politique dans les sociétés complexes de la postmodernité. (shrink)